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Dextromethorphan side effects

Across 21 first-hand reports, people mentioned a side effect 7 times (about 33 per 100 reports). The most common: liver damage, hypertension, stimulation. User reports show what people notice — they can't tell you whether Dextromethorphan is safe for you.

Reported side effects

liver damage1
hypertension1
stimulation1
brain fog1
mania1
loopy1
next-day impairment1

In their own words

“I was prescribed bupropion and will occasionally take low doses of dxm because it seems to alleviate anxiety and really low feelings for the following couple of days.”
MixedRead the discussion ↗
“I tried dextromethorphan at 30mg for a few days for stim tolerance reset and don't think it helped. 60mg at night had me loopy next day.”
Didn't helpRead the discussion ↗
“DXM absolutely annihilates my short-term working memory. Wonderful chemical though.”
MixedRead the discussion ↗

Is Dextromethorphan safe? What the research covers

AResearch: Strong62 meta-analyses · 234 randomized trials on PubMed
Cochrane Database Syst Rev · 2018
Honey for acute cough in children

Conclusion: Honey probably relieves cough symptoms to a greater extent than no treatment, diphenhydramine, and placebo, but may make little or no difference compared to dextromethorphan. Honey probably reduces cough duration better than placebo and salbutamol. There was no strong evidence for or against using honey. Most of the children received treatment for one night, which is a limitation to the results of this review. There was no difference in occurrence of adverse events between the honey and control arms.

BMJ Clin Evid · 2010
Postherpetic neuralgia

Conclusion: In this systematic review we present information relating to the effectiveness and safety of the following interventions: corticosteroids, capsaicin, dextromethorphan, dressings, gabapentin, herpes zoster vaccine, oral antiviral agents, oral opioid analgesics, lidocaine, topical antiviral agents (idoxuridine), and tricyclic antidepressants.

BMJ Clin Evid · 2007
Postherpetic neuralgia

Conclusion: In this systematic review we present information relating to the effectiveness and safety of the following interventions: corticosteroids, dextromethorphan, dressings, gabapentin, oral antiviral agents, oral opioid analgesics, topical anaesthesia (lidocaine), topical antiviral agents (idoxuridine), topical counterirritants (capsaicin), tricyclic antidepressants.

Dextromethorphan side effects: what 21 users report — PlainPill