Deplin
People mainly take Deplin for mood. Based on 3 first-hand reports. Ranked #2229 of 2,750 overall.
6
User score
Mixed0% positive33% mixed0% negative67% unclear
Of reports that state an outcome, 0% are positive.
Clinical research
Research pending
What Deplin does, according to users
Of the people who reported each effect, the share who said it got better.
betterno changeworse
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
Research data for Deplin is being compiled.
Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
15 mgdaily
Reported side effects
How often each side effect came up across all reports.
No side effects reported so far.
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“It's only been a couple days but already feeling a slight lift(!), may just be placebo of course.”
“Look into MAOI drugs..., thyroxine, deplin, stimulants”
“There is some very thin evidence that Deplin (prescription L-Methylfolate) can help augment SSRI depression treatment, but it never really caught on. Most Deplin reviews are not positive, but some people have had positiv”
Top discussions (3)
- MTHFR / genetic testing. It's been about 8 Years since it came on the scene. What's the verdict? Any actual success stories? Or is it a pointless wild goose chase? ↗
- I found a psychiatrist who practices 'DNA Medicine', analyzes DNA and then give supplement and psychopharm advice. ↗
- Convince me to take antipsychotics for my SSRI-resistant depression. ↗
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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate