Conclusion: In this systematic review we present information relating to the effectiveness and safety of the following interventions: applied relaxation, benzodiazepines, breathing retraining, brief dynamic psychotherapy, buspirone, client-centred therapy, cognitive behavioural therapy (CBT) (alone or plus drug treatments), cognitive restructuring, couple therapy, exposure (external or interoceptive), insight-orientated therapy, monoamine oxidase inhibitors (MAOIs), psychoeducation, selective serotonin reuptake inhibitors (SSRIs), self-help, and tricyclic antidepressants (imipramine).
Buspirone side effects
Across 66 first-hand reports, people mentioned a side effect 12 times (about 18 per 100 reports). The most common: dizziness, headache, heart palpitations. User reports show what people notice — they can't tell you whether Buspirone is safe for you.
Reported side effects
What got worse for some people
In their own words
“I've been on 5 mg twice a day for about a year. I can't really notice the effects on anxiety, but when I ran out...my anxiety was through the roof.”
“My daily anxiety medication is 10 mg of busipirone hcl... Take too much and I get a dizzy headache”
“Great for anxiety and drive for me but I eventually needed to up my dosage and experienced side effects. It also raises prolactin pretty significantly”
“Ive grown to like buspar, I have many OCD like mental tendencies that are significantly reduced”
“I tried buspirone that my mom was prescribed for her anxiety, but all it did was make me dizzy and give me increased anxiety”
“Buspirone gave me straight-up anxiety about 4–6 hours after taking it. Same thing happened to my partner too — we both stopped and felt way better. It also messed with my blood pressure”
Is Buspirone safe? What the research covers
Conclusion: This study underscores the efficacy and tolerability of several pharmacotherapies in managing agitation among children and adults with ASD or ID. Our findings provide robust evidence that specific treatments, such as arbaclofen, risperidone plus buspirone and omega-3 fatty acids, are both effective and well-tolerated, offering valuable therapeutic options for clinicians. The study emphasizes the need for ongoing research to ensure that treatment strategies remain aligned with the evolving clinical landscape, ultimately improving patient outcomes in this challenging population.