Conclusion: This meta-analysis suggests that B vitamin supplementation is associated with slowing of cognitive decline, especially in populations who received early intervention and intervention of long duration; the study also indicates that higher intake of dietary folate, but not B12 or B6, is associated with a reduced risk of incident dementia in non-dementia aged population. Given the prevalence of dementia cases in many countries with aging populations, public health policies should be introduced to ensure that subgroups of the population at risk have an adequate B vitamin status.
B Vitamins side effects
Across 180 first-hand reports, people mentioned a side effect 12 times (about 7 per 100 reports). The most common: anxiety, insomnia, jitteriness. User reports show what people notice — they can't tell you whether B Vitamins is safe for you.
Reported side effects
What got worse for some people
In their own words
“When I get enough or too much B vitamins I can't sleep.”
“I’ve tried lemon balm, b vitamins, magnesium glycinate, weed, so many things for anxiety. Nothing came close to that drip!”
“I’ve already tried a lot of things some basic things like magnesium, zinc, B vitamins, and PEA, tyrosine, theanine, nac, inositol, creatine, glycine, cafeine, without major results.”
“I've tried switching meds, a few b vitamins, tyrosine but nothing seems to help.”
“I've tried tyrosine and stimulating adaptogens (panax and rhodiola) and alcar and b-vitamins and TMG but nothing works.”
Is B Vitamins safe? What the research covers
Conclusion: In conclusion, maintaining optimum serum levels of nutrients and vitamins, either through a balanced and healthy diet consuming fresh fruits, vegetables, and fats or by taking appropriate supplementation, is essential in maintaining optimal health-related quality of life and reducing the risk for women during the menopausal transition and after menopause. Nevertheless, more recent studies need to be assessed to formulate adequate recommendations to achieve positive clinical outcomes.
Conclusion: The review provides evidence for the benefit of B vitamin supplementation in healthy and at-risk populations for stress, but not for depressive symptoms or anxiety. B vitamin supplementation may particularly benefit populations who are at risk due to (1) poor nutrient status or (2) poor mood status.