Conclusion: These findings add to the evidence that clopidogrel monotherapy is superior to aspirin monotherapy for MACCE prevention with no increase in the risk of bleeding, and support the preferential use of clopidogrel over aspirin for secondary prevention in patients with established CAD.
Aspirin side effects
Across 112 first-hand reports, people mentioned a side effect 21 times (about 19 per 100 reports). The most common: stomach issues, ulcers, tinnitus. User reports show what people notice — they can't tell you whether Aspirin is safe for you.
Reported side effects
In their own words
“Aspirin works better than anything I've ever tried, even cissus or other NSAIDS.”
“Aspirin: Helped circulation but I had to stop taking it due to stomach lining issue”
“I also tried Aspirin but didn't notice anything so yea...”
“weekly dose of 80mg aspirin (Covid messes with blood clotting) are what I've seen some doctors prescribe.”
“I took an aspirin and tried to distract myself... My heart continued to beat hard and slow in a very abnormal rhythm”
“I already use aspirin (reduces prostaglandin levels) if I experience especially bad hangover symptoms, but I don't usually take it because it doesn't affect the root cause. Aspirin and all other NSAIDs also increase risk of ulcers and stomach bleeding substantially, which is compounded when drinking”
Is Aspirin safe? What the research covers
Conclusion: Aspirin is associated with a reduction in ASCVD when used for primary prevention; however, it is unlikely to be clinically significant given the increase in bleeding. More importantly, aspirin's treatment effect does not increase as ASCVD risk increases, as many hypothesize. There is no suggestion from these data that use of aspirin for higher-risk primary prevention patients is beneficial.
Conclusion: The use of aspirin in individuals without cardiovascular disease was associated with a lower risk of cardiovascular events and an increased risk of major bleeding. This information may inform discussions with patients about aspirin for primary prevention of cardiovascular events and bleeding.