What are the side effects of Tamoxifen?

Users most often report fatigue, depression, low libido, headache, mood swings. Side effects came up 14 times across 298 reports.

User reports can't establish safety. PubMed lists 479 meta-analyses and 1,597 randomized trials. Talk to a doctor or pharmacist, especially if you take other medication.

Tamoxifen side effects

Across 298 first-hand reports, people mentioned a side effect 14 times (about 5 per 100 reports). The most common: fatigue, depression, low libido. User reports show what people notice — they can't tell you whether Tamoxifen is safe for you.

Reported side effects

fatigue3

depression2

low libido2

headache2

mood swings2

joint pain1

brain fog1

prolactin increase1

What got worse for some people

Libido43% worse · 57% better · of 7

In their own words

“Nolva for me has decently bad side effects so I might switch it up next time.”

MixedRead the discussion ↗

“it defos helped low test and sluggishness but it in itself had the side effect of lowering my libido”

MixedRead the discussion ↗

“On the first PCT the only side effect I had was a literal unbearable libido, and I do truly mean literal”

MixedRead the discussion ↗

“Taking Nolva in cycle isn’t really a good idea either from what I know, can affect your gains and possibly cause sides.”

Didn't helpRead the discussion ↗

Is Tamoxifen safe? What the research covers

AResearch: Strong479 meta-analyses · 1,597 randomized trials on PubMed

Lancet · 2011

Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials

Conclusion: 5 years of adjuvant tamoxifen safely reduces 15-year risks of breast cancer recurrence and death. ER status was the only recorded factor importantly predictive of the proportional reductions. Hence, the absolute risk reductions produced by tamoxifen depend on the absolute breast cancer risks (after any chemotherapy) without tamoxifen.

Ann Intern Med · 2024

Hormonal Treatments and Vaginal Moisturizers for Genitourinary Syndrome of Menopause : A Systematic Review

Conclusion: Vaginal estrogen, vaginal DHEA, oral ospemifene, and vaginal moisturizers may improve some GSM symptoms in the short term. Few long-term data exist on efficacy, comparative effectiveness, tolerability, and safety of GSM treatments.