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Amitriptyline side effects

Across 13 first-hand reports, people mentioned a side effect 5 times (about 38 per 100 reports). The most common: decreased libido, drowsiness, numbness. User reports show what people notice — they can't tell you whether Amitriptyline is safe for you.

Reported side effects

decreased libido1
drowsiness1
numbness1
constipation1
stomach issues1

In their own words

“I also take 5mg amitriptyline every night for chronic pain (and my doctor said it makes me sleep better).”
MixedRead the discussion ↗
“my sleep was amazing but after a year I started having severe constipation and gerd so I stopped both”
MixedRead the discussion ↗
“I've tried sertraline, Prozac, mitrazipine, amitriptyline, doloxetine, venlafaxine, citalopram and peicyazine.”
Didn't helpRead the discussion ↗

Is Amitriptyline safe? What the research covers

AResearch: Strong287 meta-analyses · 675 randomized trials on PubMed
J Pain · 2025
Management of Central Poststroke Pain: Systematic Review and Meta-analysis

Conclusion: PERSPECTIVE: This article presents a top-down and bottom-up overview of evidence for the effectiveness of different pharmacological, physical, and neuromodulation treatments of CPSP. This review could provide clinicians with a comprehensive understanding of the effectiveness and tolerability of different treatment types.

Amitriptyline side effects: what 13 users report — PlainPill