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ADHD Medications side effects

Across 5 first-hand reports, people mentioned a side effect 5 times (about 100 per 100 reports). The most common: agitation, instability, anxiety. User reports show what people notice — they can't tell you whether ADHD Medications is safe for you.

Reported side effects

agitation1
instability1
anxiety1
insomnia1
anger1

In their own words

“I do not take ADHD meds because they make my anxiety and insomnia worse and a whole host of other reasons.”
Didn't helpRead the discussion ↗
“They all made me ANGRY. They helped me with hyperactivity and focus for the first few weeks”
MixedRead the discussion ↗
“I've tried ADHD meds and they just make him crazy and unstable.”
Didn't helpRead the discussion ↗

Is ADHD Medications safe? What the research covers

AResearch: Strong52 meta-analyses · 17 randomized trials on PubMed
Lancet Psychiatry · 2018
Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis

Conclusion: Our findings represent the most comprehensive available evidence base to inform patients, families, clinicians, guideline developers, and policymakers on the choice of ADHD medications across age groups. Taking into account both efficacy and safety, evidence from this meta-analysis supports methylphenidate in children and adolescents, and amphetamines in adults, as preferred first-choice medications for the short-term treatment of ADHD. New research should be funded urgently to assess long-term effects of these drugs.

Lancet Psychiatry · 2025
Comparative cardiovascular safety of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis

Conclusion: Practitioners should monitor blood pressure and pulse in patients with ADHD treated with any pharmacological intervention, and not stimulants only. Given the short duration of available randomised controlled trials, new research providing insights on the causal effects of ADHD medications on cardiovascular parameters in the longer term should be funded.

ADHD Medications side effects: what 5 users report — PlainPill