Raloxifene vs Tamoxifen for hormones
Short answer: For hormones, more users report improvement with Tamoxifen — 98% of 49 reports, versus 88% of 8 for Raloxifene.
Raloxifene has 130 meta-analyses and 431 randomized trials on PubMed; Tamoxifen has 479 and 1,597.
Based on 37 reports about Raloxifene and 298 about Tamoxifen. Not medical advice.
| Raloxifene Medication | Tamoxifen Medication | |
|---|---|---|
| Users say it helped | 67%helped9 reports · few reports | 64%helped75 reports · medium confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 130 / 431 | 479 / 1,597 |
| Mainly used for | ||
| Hormones % reporting improvement | 88% (8) | 98% (49) |
| Libido % reporting improvement | — | 57% (7) |
| Energy % reporting improvement | — | 100% (5) |
| Common side effects | feeling unwell | fatigue, depression, low libido, headache |
| Typical dose reported | Not listed | Not listed |
Bisphosphonates, denosumab, abaloparatide, teriparatide, and romosozumab, followed by alendronate, reduce clinical fractures in postmenopausal females with osteoporosis. Abaloparatide and teriparatide increased WAEs; longer duration bisphosphonate use may increase AFF and ONJ risk though these events were rare.
Ann Intern Med, 2023 ↗“I experienced this running the same stack. Ran a full regiment of Raloxifene and reversed it entirely.”
5 years of adjuvant tamoxifen safely reduces 15-year risks of breast cancer recurrence and death. ER status was the only recorded factor importantly predictive of the proportional reductions. Hence, the absolute risk reductions produced by tamoxifen depend on the absolute breast cancer risks (after any chemotherapy) without tamoxifen.
Lancet, 2011 ↗“Dosage 5 mg starting at week 2. I upped the dose to 10 mg mid cycle due to slightly feeling suppressed.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate