Alpha-Gpc vs Phosphatidylcholine for memory
Short answer: For memory, more users report improvement with Alpha-Gpc — 93% of 72 reports, versus 86% of 7 for Phosphatidylcholine.
Alpha-Gpc has 1 meta-analyses and 13 randomized trials on PubMed; Phosphatidylcholine has 45 and 248.
Based on 1,096 reports about Alpha-Gpc and 45 about Phosphatidylcholine. Not medical advice.
| Alpha-Gpc Supplement | Phosphatidylcholine Supplement | |
|---|---|---|
| Users say it helped | 54%helped384 reports · high confidence | 54%helped6 reports · few reports |
| Verdict | Mixed | Not enough data |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 1 / 13 | 45 / 248 |
| Mainly used for | ||
| Focus % reporting improvement | 89% (199) | 100% (2) |
| Memory % reporting improvement | 93% (72) | 86% (7) |
| Mood % reporting improvement | 39% (70) | — |
| Energy % reporting improvement | 84% (31) | — |
| Anxiety % reporting improvement | 47% (15) | — |
| Common side effects | depression, headache, irritability, nausea | short term, intoxicated feeling |
| Typical dose reported | 100 mg / daily | 840 mg / daily |
α-GPC alone or in combination with donepezil improved cognition, behavior, and functional outcomes among patients with neurological conditions associated with cerebrovascular injury.
J Alzheimers Dis, 2023 ↗“Since I started with L-Tyrosine and Alpha GPC each morning, 3-4 weeks ago. I don’t know which is more effective. But I now feel like I’m on ADHD meds. It’s been transformative.”
Taken together, our integrated results revealed that metabolic changes in the peripheral blood were associated with MDD, particularly decreased L-tryptophan and kynurenic acid levels, and alterations in the tryptophan-kynurenine and fatty acid metabolism pathways. Our findings may facilitate biomarker development and the elucidation of the molecular mechanisms that underly MDD.
Mol Psychiatry, 2021 ↗“I had much better luck combining citicholine, phosphatidylcholine as daily supplements”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate