PlainPill

NR vs Rapamycin for longevity

Short answer: For longevity, users rate them about the same: 100% report improvement with NR (9 reports) and 100% with Rapamycin (7 reports).

Rapamycin has 497 meta-analyses and 1,245 randomized trials on PubMed; the other has not been graded.

Based on 140 reports about NR and 61 about Rapamycin. Not medical advice.

NR
Supplement
Rapamycin
Medication
Users say it helped56%helped35 reports · medium confidence28%helped11 reports · few reports
Verdict
Mixed
Mixed
ResearchNot gradedAResearch: Strong
Meta-analyses / RCTs—497 / 1,245
Mainly used for
Longevity
% reporting improvement
100% (9)100% (7)
Energy
% reporting improvement
100% (15)—
Recovery
% reporting improvement
100% (6)50% (2)
Pain & inflammation
% reporting improvement
86% (7)—
Common side effectsbrain fogfatigue, slow wound, canker sores, hyperglycemia
Typical dose reported250 mg / dailyNot listed
NR
What a user said
“I have noticed a huge improvement with those for symptoms and conditions similar to yours.”
Full NR profile →
Rapamycin
Latest review conclusion

The majority of the patients reported adverse events limited to grade 1 or 2. On the whole, the data presented herein confirm the findings of previous studies on the relative safety of everolimus, a targeted therapeutic agent, which differs from that of conventional chemotherapy, and highlight the potential adverse events associated with the therapeutic use of everolimus.

Int J Oncol, 2021 ↗
What a user said
“I've noticed a 10% increase in HDL and some fatigue the day after taking more than 6mg.”
Full Rapamycin profile →

Related comparisons

Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate