Melatonin vs NR for longevity
Short answer: For longevity, users rate them about the same: 100% report improvement with Melatonin (7 reports) and 100% with NR (9 reports).
Melatonin has 688 meta-analyses and 1,128 randomized trials on PubMed; the other has not been graded.
Based on 1,370 reports about Melatonin and 140 about NR. Not medical advice.
| Melatonin Supplement | NR Supplement | |
|---|---|---|
| Users say it helped | 42%helped726 reports · high confidence | 56%helped35 reports · medium confidence |
| Verdict | Mixed | Mixed |
| Research | AResearch: Strong | Not graded |
| Meta-analyses / RCTs | 688 / 1,128 | — |
| Mainly used for | ||
| Sleep % reporting improvement | 78% (915) | 100% (4) |
| Energy % reporting improvement | 32% (25) | 100% (15) |
| Mood % reporting improvement | 32% (37) | 100% (3) |
| Anxiety % reporting improvement | 44% (16) | — |
| Longevity % reporting improvement | 100% (7) | 100% (9) |
| Common side effects | drowsiness, vivid dreams, fatigue, depression | brain fog |
| Typical dose reported | 0.5 mg / bedtime | 250 mg / daily |
Overall, eszopiclone and lemborexant had a favorable profile, but eszopiclone might cause substantial adverse events and safety data on lemborexant were inconclusive. Doxepin, seltorexant, and zaleplon were well tolerated, but data on efficacy and other important outcomes were scarce and do not allow firm conclusions. Many licensed drugs (including benzodiazepines, daridorexant, suvorexant, and trazodone) can be effective in the acute treatment of insomnia but are associated with poor tolerability, or information about long-term effects is not available. Melatonin, ramelteon, and non-licensed
Lancet, 2022 ↗“I have taken it nightly for 19 years. Doses ranging from .1 to 10mg. Right now I take 3mg per night. It helps me sleep.”
“I have noticed a huge improvement with those for symptoms and conditions similar to yours.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate