Nefiracetam vs Oxiracetam for mood
Short answer: For mood, more users report improvement with Nefiracetam — 75% of 8 reports, versus 68% of 22 for Oxiracetam.
Nefiracetam has 1 meta-analyses and 3 randomized trials on PubMed; Oxiracetam has 5 and 19.
Based on 31 reports about Nefiracetam and 495 about Oxiracetam. Not medical advice.
| Nefiracetam Supplement | Oxiracetam Supplement | |
|---|---|---|
| Users say it helped | 73%helped14 reports · few reports | 66%helped218 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 1 / 3 | 5 / 19 |
| Mainly used for | ||
| Focus % reporting improvement | 100% (7) | 90% (148) |
| Memory % reporting improvement | 100% (4) | 98% (51) |
| Energy % reporting improvement | — | 95% (37) |
| Mood % reporting improvement | 75% (8) | 68% (22) |
| Anxiety % reporting improvement | — | 64% (14) |
| Common side effects | kidney pain, testicular shrinkage, sneeze, headache | irritability, insomnia, headache, hypomania |
| Typical dose reported | 5 mg/kg / 2x/day | 1500-2250 mg / daily |
Several interventions, including escitalopram, donepezil, motor relearning programs, strategy training, and rTMS, have demonstrated potential effectiveness in treating post-stroke apathy. Nevertheless, evidence remains scarce and heterogeneous, underscoring the need for larger, high-quality randomized controlled trials to establish definitive treatment guidelines.
Front Neurol, 2025 ↗“I love this one. Nice little mood brightener. ... it helps me connect the dots at work and when doing everyday activities.”
This study enhances the understanding of the relative benefits and risks associated with various VaD treatments, providing a valuable reference for clinical decision-making.
Front Pharmacol, 2024 ↗“Oxi gave me a significant increase in focus, to the point where I could work for 2-3 hours without even checking facebook. / It also helped me with memory (was clearly retaining more info in both short-term and long-term).”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate