PlainPill
SupplementFocusMood

Nefiracetam

People mainly take Nefiracetam for focus, mood. Based on 25 first-hand reports and 1 meta-analyses & systematic reviews in the medical literature. Ranked #191 of 2,750 overall.

Compare with…Alternatives for focus
46
User score
Mostly positive
32% positive8% mixed8% negative52% unclear

Of reports that state an outcome, 67% are positive.

Clinical research
BModerate research base
1
meta-analyses
3
RCTs
133
papers

What Nefiracetam does, according to users

Of the people who reported each effect, the share who said it got better.

Focus100% of 7Mood71% of 7
3 more with fewer than 3 reports
Memory100% of 1Anxiety100% of 1Energy100% of 1
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

BModerate research base

At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.

Front Neurol · 2025 · Meta-analysis / systematic review
Treatment of apathy in stroke patients: a systematic review

Conclusion: Several interventions, including escitalopram, donepezil, motor relearning programs, strategy training, and rTMS, have demonstrated potential effectiveness in treating post-stroke apathy. Nevertheless, evidence remains scarce and heterogeneous, underscoring the need for larger, high-quality randomized controlled trials to establish definitive treatment guidelines.

PubMed 41383225 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

1/2 teaspoonas reported
100 mgas reported
multiple days in a rowas reported
150-300 mg3x daily at least 5 days/week
50 mgas reported

Reported side effects

How often each side effect came up across all reports.

kidney pain ×2testicular shrinkage ×1sneeze ×1headache ×1emotional numbing ×1blunted emotions ×1kidney toxicity ×1testicular toxicity ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“the OP left off Neph as well, but that may shrink your testicals”
Source discussion ↗
“I get 1 caps and cut pram and nefi with Alpha_GPC 50/50”
Source discussion ↗
“especially the really potent ones like Noopept, Nefi, and Pram”
Source discussion ↗
“nefiracetam - although it may well be toxic to the kidneys and more importantly the precious testes.”
Source discussion ↗
“50mg Nefiracetam”
Source discussion ↗
Top discussions (5)

Other options for focus

Retatrutide
Peptide · 440 reports
71
83% report better focus
Mostly positiveBResearch: Moderate
Caffeine + L-Theanine
Supplement · 90 reports
69
94% report better focus
Mostly positive
Testosterone Cypionate
Medication · 42 reports
68
100% report better focus
Mostly positiveBResearch: Moderate
Tirzepatide
Medication · 405 reports
68
67% report better focus
Mostly positiveAResearch: Strong
Exercise
Lifestyle · 729 reports
63
95% report better focus
Mostly positive
Intermittent Fasting
Lifestyle · 255 reports
63
92% report better focus
Mostly positive

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate