Melatonin vs Metformin for longevity
Short answer: For longevity, users rate them about the same: 100% report improvement with Melatonin (7 reports) and 100% with Metformin (11 reports).
Melatonin has 688 meta-analyses and 1,128 randomized trials on PubMed; Metformin has 1,367 and 3,450.
Based on 1,370 reports about Melatonin and 175 about Metformin. Not medical advice.
| Melatonin Supplement | Metformin Medication | |
|---|---|---|
| Users say it helped | 42%helped726 reports · high confidence | 29%helped67 reports · medium confidence |
| Verdict | Mixed | Mixed |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 688 / 1,128 | 1,367 / 3,450 |
| Mainly used for | ||
| Sleep % reporting improvement | 78% (915) | 100% (2) |
| Mood % reporting improvement | 32% (37) | 50% (2) |
| Energy % reporting improvement | 32% (25) | 40% (10) |
| Blood sugar % reporting improvement | 100% (3) | 96% (27) |
| Longevity % reporting improvement | 100% (7) | 100% (11) |
| Common side effects | drowsiness, vivid dreams, fatigue, depression | stomach issues, diarrhea, b12 depletion, nausea |
| Typical dose reported | 0.5 mg / bedtime | Not listed |
Overall, eszopiclone and lemborexant had a favorable profile, but eszopiclone might cause substantial adverse events and safety data on lemborexant were inconclusive. Doxepin, seltorexant, and zaleplon were well tolerated, but data on efficacy and other important outcomes were scarce and do not allow firm conclusions. Many licensed drugs (including benzodiazepines, daridorexant, suvorexant, and trazodone) can be effective in the acute treatment of insomnia but are associated with poor tolerability, or information about long-term effects is not available. Melatonin, ramelteon, and non-licensed
Lancet, 2022 ↗“I have taken it nightly for 19 years. Doses ranging from .1 to 10mg. Right now I take 3mg per night. It helps me sleep.”
The choice of metformin or COCP treatment should be based on symptoms, noting some biochemical benefits from combination treatment targeting both major endocrine disturbances seen in PCOS (hyperinsulinemia and hyperandrogenism).
J Clin Endocrinol Metab, 2024 ↗“Metformin currently has enough data for me personally to feel comfortable not only taking it myself (and my wife), but also recommending it to my patients.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate