PlainPill

Magnesium vs NAC for anxiety

Short answer: For anxiety, users rate them about the same: 89% report improvement with Magnesium (226 reports) and 90% with NAC (259 reports).

Magnesium has 82 meta-analyses and 210 randomized trials on PubMed; NAC has 387 and 767.

Based on 1,893 reports about Magnesium and 1,645 about NAC. Not medical advice.

Magnesium
Supplement
NAC
Supplement
User score5149
Verdict
Mostly positive
Mixed
Positive
of reports that state an outcome
72%55%
Reports1,8931,645
ResearchAResearch: StrongAResearch: Strong
Meta-analyses / RCTs82 / 210387 / 767
Mainly used for
Weight loss
% reporting improvement
—75% (4)
Appetite
% reporting improvement
100% (2)90% (31)
Focus
% reporting improvement
77% (39)82% (156)
Energy
% reporting improvement
75% (73)74% (78)
Sleep
% reporting improvement
87% (331)71% (41)
Anxiety
% reporting improvement
89% (226)90% (259)
Mood
% reporting improvement
80% (99)65% (274)
Memory
% reporting improvement
100% (7)79% (14)
Performance
% reporting improvement
87% (15)75% (8)
Recovery
% reporting improvement
96% (24)86% (14)
Pain & inflammation
% reporting improvement
91% (33)86% (28)
Digestion
% reporting improvement
83% (29)72% (18)
Libido
% reporting improvement
62% (13)29% (7)
Hormones
% reporting improvement
91% (22)88% (8)
Blood sugar
% reporting improvement
100% (3)100% (3)
Heart & lipids
% reporting improvement
95% (22)67% (12)
Skin & hair
% reporting improvement
100% (2)89% (18)
Immunity
% reporting improvement
86% (7)97% (34)
Longevity
% reporting improvement
100% (3)100% (7)
Common side effectsdiarrhea, drowsiness, stomach issues, vivid dreamsanhedonia, fatigue, stomach issues, depression
Typical dose reporteddailyas needed
Magnesium
Latest review conclusion

This review confirms that the quality of literature is substandard for physicians to make well-informed recommendations on usage of oral magnesium for older adults with insomnia. However, given that oral magnesium is very cheap and widely available, RCT evidence may support oral magnesium supplements (less than 1 g quantities given up to three times a day) for insomnia symptoms.

BMC Complement Med Ther, 2021 ↗
What a user said
“after supplementing with 400mg of Magnesium daily. Winter blues hit me hard and my multivitamin wasn't doing any justice, but once I began supplementing Magnesium, everything changed.”
Full Magnesium profile →
NAC
Latest review conclusion

Taken together, these preliminary findings suggest that dietetic approaches might be included as part of BD treatment. Also considering the high risk of metabolic disorders in individuals with BD, they should be encouraged to choose healthy dietary lifestyles, including daily intake of fruits, vegetables, seafood and whole grains.

Nutr Neurosci, 2023 ↗
What a user said
“NAC has helped me stay calm and reduce anxiety as well as gives me loads of energy if I am sleep deprived.”
Full NAC profile →

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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate