L-Citrulline vs PT-141 for libido
Short answer: For libido, more users report improvement with L-Citrulline — 98% of 48 reports, versus 92% of 75 for PT-141.
L-Citrulline has 14 meta-analyses and 101 randomized trials on PubMed; PT-141 has 0 and 4.
Based on 231 reports about L-Citrulline and 123 about PT-141. Not medical advice.
| L-Citrulline Supplement | PT-141 Peptide | |
|---|---|---|
| Users say it helped | 77%helped99 reports · medium confidence | 53%helped74 reports · medium confidence |
| Verdict | Mostly positive | Mixed |
| Research | AResearch: Strong | CResearch: Limited |
| Meta-analyses / RCTs | 14 / 101 | 0 / 4 |
| Mainly used for | ||
| Libido % reporting improvement | 98% (48) | 92% (75) |
| Performance % reporting improvement | 98% (45) | 100% (9) |
| Heart & lipids % reporting improvement | 95% (22) | — |
| Energy % reporting improvement | 100% (11) | 50% (2) |
| Mood % reporting improvement | 100% (2) | 33% (6) |
| Common side effects | cold sore, dizziness, headache, increased urination | nausea, flushing, headache, anhedonia |
| Typical dose reported | 8 g / 3x/week | Not listed |
Foods rich in polyphenols and nitrate provide trivial benefits for endurance exercise performance, although these effects may be food dependent. Highly trained endurance athletes do not appear to benefit from consuming nitrate-rich foods but may benefit from polyphenol consumption. Further research into food sources, dosage and supplementation duration to optimise the ergogenic response to polyphenol consumption is warranted. Further studies should evaluate whether differential sex-based responses to nitrate and polyphenol consumption are attributable to physiological differences or sample siz
J Int Soc Sports Nutr, 2021 ↗“Something I found that makes my meds work way better is Citrulline 2g + Arginine 2g twice daily.”
“Holy crap, I was blown away at the effectiveness of this. First noticed it taking effects when every half decent girl who walked by, I wanted to rip their clothes off. Refractory periods of 3-5 mins and ready to go again.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate