PlainPill

Bromantane vs Ketamine for mood

Short answer: For mood, users rate them about the same: 95% report improvement with Bromantane (74 reports) and 97% with Ketamine (62 reports).

Bromantane has 1 meta-analyses and 0 randomized trials on PubMed; Ketamine has 854 and 1,957.

Based on 518 reports about Bromantane and 141 about Ketamine. Not medical advice.

Bromantane
Supplement
Ketamine
Medication
Users say it helped69%helped186 reports · high confidence65%helped65 reports · medium confidence
Verdict
Mostly positive
Mostly positive
ResearchBResearch: ModerateAResearch: Strong
Meta-analyses / RCTs1 / 0854 / 1,957
Mainly used for
Mood
% reporting improvement
95% (74)97% (62)
Energy
% reporting improvement
96% (90)100% (3)
Focus
% reporting improvement
89% (70)100% (3)
Anxiety
% reporting improvement
96% (46)90% (10)
Performance
% reporting improvement
89% (9)—
Common side effectsjitteriness, insomnia, headache, irritabilitydissociation, headache, fatigue, insomnia
Typical dose reported130 mg / dailyNot listed
Bromantane
Latest review conclusion

The data from the meta-analysis showed that plant adaptogens could provide a number of benefits in the treatment of chronic fatigue, cognitive impairment, and immune protection. In the future, there is great potential to register medicinal products that contain plant adaptogens for therapeutic purposes.

Nutrients, 2021 ↗
What a user said
“Bromantane will reset dopamine baseline and stim tolerance but it also gives me crazy energy like a kid again.”
Full Bromantane profile →
Ketamine
Latest review conclusion

Compared with etomidate, ketamine probably results in more hemodynamic instability during the peri-intubation period and appears to have no effect on successful intubation on the first attempt or mortality. However, ketamine results in decreased need for the initiation of vasopressor use and decreases adrenal suppression compared with etomidate.

Crit Care Med, 2025 ↗
What a user said
“One thing that has really helped me tremendously, without the nasty side effects of SSRIs, is Ketamine infusions.”
Full Ketamine profile →

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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate