Ipamorelin vs Retatrutide for weight loss
Short answer: For weight loss, users rate them about the same: 93% report improvement with Ipamorelin (43 reports) and 91% with Retatrutide (222 reports).
Ipamorelin has 0 meta-analyses and 2 randomized trials on PubMed; Retatrutide has 22 and 6.
Based on 378 reports about Ipamorelin and 446 about Retatrutide. Not medical advice.
| Ipamorelin Peptide | Retatrutide Peptide | |
|---|---|---|
| User score | 18 | 71 |
| Verdict | Mostly positive | Mostly positive |
| Positive of reports that state an outcome | 63% | 76% |
| Reports | 378 | 446 |
| Research | CResearch: Limited | BResearch: Moderate |
| Meta-analyses / RCTs | 0 / 2 | 22 / 6 |
| Mainly used for | ||
| Weight loss % reporting improvement | 93% (43) | 91% (222) |
| Appetite % reporting improvement | 25% (12) | 73% (84) |
| Focus % reporting improvement | 100% (5) | 83% (6) |
| Energy % reporting improvement | 88% (17) | 69% (75) |
| Sleep % reporting improvement | 77% (65) | 31% (26) |
| Anxiety % reporting improvement | — | 40% (5) |
| Mood % reporting improvement | 100% (8) | 66% (32) |
| Performance % reporting improvement | 82% (33) | 82% (33) |
| Recovery % reporting improvement | 88% (43) | 100% (8) |
| Pain & inflammation % reporting improvement | 100% (13) | 78% (9) |
| Digestion % reporting improvement | 33% (3) | 46% (13) |
| Libido % reporting improvement | — | 25% (12) |
| Hormones % reporting improvement | 72% (18) | 100% (13) |
| Blood sugar % reporting improvement | 0% (3) | 75% (4) |
| Heart & lipids % reporting improvement | — | 37% (19) |
| Skin & hair % reporting improvement | 91% (11) | — |
| Common side effects | insomnia, flushing, water retention, fatigue | nausea, fatigue, stomach issues, insomnia |
| Typical dose reported | Not listed | Not listed |
“CJC-1295, Ipamorelin, rHGH all help. Helped me recover from Phenibut overuse and dependence, and heavy stimulants.”
This systematic review identifies the state and mechanism of action of emerging pharmacotherapies undergoing or having completed phase 2 and phase 3 clinical trials. The information provided herein furthers the understanding of obesity management, implying direct clinical implications and stimulating research initiatives.
Pharmacol Rev, 2025 ↗“Drastically reduced appetite: At 5mg, I experienced near-total suppression of hunger and cravings. Steady, effortless fat loss: I didn't have to track macros obsessively or do extreme cardio.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate