Ibogaine vs Psilocybin for memory
Short answer: For memory, more users report improvement with Ibogaine — 100% of 2 reports, versus 93% of 15 for Psilocybin.
Ibogaine has 13 meta-analyses and 3 randomized trials on PubMed; Psilocybin has 189 and 138.
Based on 17 reports about Ibogaine and 319 about Psilocybin. Not medical advice.
| Ibogaine Substance | Psilocybin Substance | |
|---|---|---|
| Users say it helped | 80%helped5 reports · few reports | 75%helped140 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 13 / 3 | 189 / 138 |
| Mainly used for | ||
| Mood % reporting improvement | — | 90% (110) |
| Anxiety % reporting improvement | — | 87% (45) |
| Focus % reporting improvement | — | 93% (29) |
| Memory % reporting improvement | 100% (2) | 93% (15) |
| Energy % reporting improvement | — | 100% (13) |
| Common side effects | medical complications | mania, hppd, psychosis risk, paranoia |
| Typical dose reported | — | 0.2-0.5 g / occasional |
Our results warrant further studies into the clinical efficacy of ibogaine in SUD patients in reducing craving and substance use, but close monitoring of the patients is recommended because of the possible toxic effects. In addition, more work is needed to unravel the neuropharmacological working mechanisms of ibogaine and to investigate its effects on heart rhythm.
Transl Psychiatry, 2016 ↗“Ibogaine worked. I literally saw my brain heal. It's extremely unsafe to do it alone; a clinic is a must.”
A review of open-label trials showed robust decreases in depressive symptoms following psilocybin administration. These findings provide preliminary evidence for antidepressant efficacy with psilocybin-assisted psychotherapy, however, further studies are needed to evaluate safety and efficacy and to optimize treatment protocols.
Psychiatry Res, 2023 ↗“Mushrooms make me a better husband and a better human all around. Sometimes I don’t feel the urge to have sex while I’m on a dose, but I feel much more connected afterward. Low dose is definitely an aphrodisiac in my experience.”
Related comparisons
Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate