Dmt vs Psilocybin for mood
Short answer: For mood, more users report improvement with Dmt — 100% of 4 reports, versus 90% of 110 for Psilocybin.
Dmt has 207 meta-analyses and 121 randomized trials on PubMed; Psilocybin has 189 and 138.
Based on 25 reports about Dmt and 319 about Psilocybin. Not medical advice.
| Dmt Substance | Psilocybin Substance | |
|---|---|---|
| Users say it helped | 75%helped8 reports · few reports | 75%helped140 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 207 / 121 | 189 / 138 |
| Mainly used for | ||
| Mood % reporting improvement | 100% (4) | 90% (110) |
| Anxiety % reporting improvement | — | 87% (45) |
| Focus % reporting improvement | — | 93% (29) |
| Memory % reporting improvement | — | 93% (15) |
| Energy % reporting improvement | — | 100% (13) |
| Common side effects | nausea | mania, hppd, psychosis risk, paranoia |
| Typical dose reported | 10 mg | 0.2-0.5 g / occasional |
We found strong evidence that antidepressants differ markedly in their physiological effects, particularly for cardiometabolic parameters. Treatment guidelines should be updated to reflect differences in physiological risk, but choice of antidepressant should be made on an individual basis, considering clinical presentation and preferences of patients, carers, and clinicians.
Lancet, 2025 ↗“I also frequently use DMT,and I'm convinced that it has had a huge influence on my circadian rhythms.”
A review of open-label trials showed robust decreases in depressive symptoms following psilocybin administration. These findings provide preliminary evidence for antidepressant efficacy with psilocybin-assisted psychotherapy, however, further studies are needed to evaluate safety and efficacy and to optimize treatment protocols.
Psychiatry Res, 2023 ↗“Mushrooms make me a better husband and a better human all around. Sometimes I don’t feel the urge to have sex while I’m on a dose, but I feel much more connected afterward. Low dose is definitely an aphrodisiac in my experience.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate