PlainPill

Garlic vs L-Lysine for immunity

Short answer: For immunity, users rate them about the same: 100% report improvement with Garlic (8 reports) and 100% with L-Lysine (9 reports).

Garlic has 142 meta-analyses and 194 randomized trials on PubMed; L-Lysine has 7 and 59.

Based on 133 reports about Garlic and 53 about L-Lysine. Not medical advice.

Garlic
Supplement
L-Lysine
Supplement
Users say it helped77%helped40 reports · medium confidence65%helped21 reports · medium confidence
Verdict
Mostly positive
Mostly positive
ResearchAResearch: StrongAResearch: Strong
Meta-analyses / RCTs142 / 1947 / 59
Mainly used for
Heart & lipids
% reporting improvement
95% (19)—
Immunity
% reporting improvement
100% (8)100% (9)
Common side effectsnausea, headache, garlic smell, constipationstomach issues
Typical dose reported500 mg / 2x daily2 g / before bed
Garlic
Latest review conclusion

Conclusion: There is moderate to high level of evidence from randomized controlled trials that the Ayurvedic herbs guggulu, garlic, and black cumin are moderately effective for reducing hypercholesterolemia. In addition, minimal evidence was found for any side effects associated with these herbs, positioning them as safe adjuvants to conventional treatments.

Medicina (Kaunas), 2021 ↗
What a user said
“For me, it's garlic that works. I use these capsules called Allacin Max, and at the first hint of a cold or a bug I start taking them and the cold never develops into anything.”
Full Garlic profile →
L-Lysine
Latest review conclusion

Based primarily on case reports ornithine levels can be reduced by using a protein restricted diet, pyridoxine supplementation (variation-dependent) and/or lysine supplementation. The lack of pre-defined clinical outcome measures and structural follow-up in all included studies impeded conclusions on clinical effectiveness. Future research should be aimed at 1) Unravelling the OAT biochemical pathway to identify other possible pathologic metabolites besides ornithine, 2) Pre-defining GACR specific clinical outcome measures, and 3) Establishing an international historical cohort.

Mol Genet Metab, 2021 ↗
What a user said
“Finally, I started to take L-lysine for a different issue. Immediately I saw that I could lay my head down at night and go to sleep like I could before. That was several months ago and I continue to sleep regularly.”
Full L-Lysine profile →

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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate