Eca Stack vs Retatrutide for weight loss
Short answer: For weight loss, more users report improvement with Eca Stack — 100% of 28 reports, versus 92% of 228 for Retatrutide.
Retatrutide has 22 meta-analyses and 6 randomized trials on PubMed; the other has not been graded.
Based on 60 reports about Eca Stack and 460 about Retatrutide. Not medical advice.
| Eca Stack Substance | Retatrutide Peptide | |
|---|---|---|
| Users say it helped | 74%helped32 reports · medium confidence | 76%helped327 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | Not graded | BResearch: Moderate |
| Meta-analyses / RCTs | — | 22 / 6 |
| Mainly used for | ||
| Weight loss % reporting improvement | 100% (28) | 92% (228) |
| Appetite % reporting improvement | 67% (12) | 73% (86) |
| Energy % reporting improvement | 92% (12) | 69% (75) |
| Performance % reporting improvement | 100% (2) | 82% (33) |
| Mood % reporting improvement | — | 66% (32) |
| Common side effects | jitteriness, insomnia, increased heart, headache | nausea, fatigue, stomach issues, insomnia |
| Typical dose reported | 25 mg ephedrine, 200-250 mg caffeine, 81 mg aspirin | Not listed |
“I used to feel hungry every two or three hours, but now I am very rarely hungry. I've lost 8 pounds since Friday while only doing cardio. I feel fine - no jitters, nausea, etc.”
This systematic review identifies the state and mechanism of action of emerging pharmacotherapies undergoing or having completed phase 2 and phase 3 clinical trials. The information provided herein furthers the understanding of obesity management, implying direct clinical implications and stimulating research initiatives.
Pharmacol Rev, 2025 ↗“Drastically reduced appetite: At 5mg, I experienced near-total suppression of hunger and cravings. Steady, effortless fat loss: I didn't have to track macros obsessively or do extreme cardio.”
Related comparisons
Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate