Curcumin vs Metformin for longevity
Short answer: For longevity, users rate them about the same: 100% report improvement with Curcumin (6 reports) and 100% with Metformin (11 reports).
Curcumin has 538 meta-analyses and 553 randomized trials on PubMed; Metformin has 1,367 and 3,450.
Based on 544 reports about Curcumin and 175 about Metformin. Not medical advice.
| Curcumin Supplement | Metformin Medication | |
|---|---|---|
| Users say it helped | 61%helped180 reports · high confidence | 29%helped67 reports · medium confidence |
| Verdict | Mostly positive | Mixed |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 538 / 553 | 1,367 / 3,450 |
| Mainly used for | ||
| Pain & inflammation % reporting improvement | 91% (104) | — |
| Mood % reporting improvement | 96% (45) | 50% (2) |
| Blood sugar % reporting improvement | — | 96% (27) |
| Performance % reporting improvement | 33% (3) | 0% (15) |
| Longevity % reporting improvement | 100% (6) | 100% (11) |
| Common side effects | vivid dreams, headache, nausea, dht suppression | stomach issues, diarrhea, b12 depletion, nausea |
| Typical dose reported | 1000 mg / daily | Not listed |
Curcumin and Curcuma longa Extract may improve symptoms and inflammation levels in people with arthritis. However, due to the low quality and small quantity of RCTs, the conclusions need to be interpreted carefully.
Front Immunol, 2022 ↗“I recently stopped taking Curcumin because of its affect on DHT and I was looking for an alternative measure to deal with inflammation as I feel it really helped with anxiety/depression.”
The choice of metformin or COCP treatment should be based on symptoms, noting some biochemical benefits from combination treatment targeting both major endocrine disturbances seen in PCOS (hyperinsulinemia and hyperandrogenism).
J Clin Endocrinol Metab, 2024 ↗“Metformin currently has enough data for me personally to feel comfortable not only taking it myself (and my wife), but also recommending it to my patients.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate