Alpha-Gpc vs Creatine for memory
Short answer: For memory, users rate them about the same: 93% report improvement with Alpha-Gpc (72 reports) and 93% with Creatine (85 reports).
Alpha-Gpc has 1 meta-analyses and 13 randomized trials on PubMed; Creatine has 763 and 2,794.
Based on 1,096 reports about Alpha-Gpc and 2,279 about Creatine. Not medical advice.
| Alpha-Gpc Supplement | Creatine Supplement | |
|---|---|---|
| Users say it helped | 54%helped384 reports · high confidence | 72%helped1,048 reports · high confidence |
| Verdict | Mixed | Mostly positive |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 1 / 13 | 763 / 2,794 |
| Mainly used for | ||
| Performance % reporting improvement | 93% (14) | 98% (542) |
| Focus % reporting improvement | 89% (199) | 93% (249) |
| Energy % reporting improvement | 84% (31) | 97% (268) |
| Mood % reporting improvement | 39% (70) | 87% (125) |
| Memory % reporting improvement | 93% (72) | 93% (85) |
| Common side effects | depression, headache, irritability, nausea | stomach issues, hair loss, insomnia, water retention |
| Typical dose reported | 100 mg / daily | 5 g / daily |
α-GPC alone or in combination with donepezil improved cognition, behavior, and functional outcomes among patients with neurological conditions associated with cerebrovascular injury.
J Alzheimers Dis, 2023 ↗“Since I started with L-Tyrosine and Alpha GPC each morning, 3-4 weeks ago. I don’t know which is more effective. But I now feel like I’m on ADHD meds. It’s been transformative.”
The results of the meta-analysis suggest that creatine supplementation did not significantly alter serum creatinine levels (standardized mean difference = 0.48, 95% confidence interval 0.24-0.73, P = .001, I2 = 22%), and did not alter plasma urea values (standardized mean difference = 1.10, 95% confidence interval 0.34-1.85, P = .004, I2 = 28%). The findings indicate that creatine supplementation does not induce renal damage in the studied amounts and durations.
J Ren Nutr, 2019 ↗“I actually feel a lot better. Mentally clearer and more balanced, like I have my brain back.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate