What are the side effects of Tianeptine Sulfate?

Users most often report drowsiness, feeling odd, insomnia, stimulation, emotional blunting. Side effects came up 8 times across 34 reports.

Tianeptine Sulfate side effects

Q: Is Tianeptine Sulfate safe?

User reports can't establish safety. PubMed lists 18 meta-analyses and 42 randomized trials. Talk to a doctor or pharmacist, especially if you take other medication.

Across 34 first-hand reports, people mentioned a side effect 8 times (about 24 per 100 reports). The most common: drowsiness, feeling odd, insomnia. User reports show what people notice — they can't tell you whether Tianeptine Sulfate is safe for you.

Reported side effects

drowsiness1

feeling odd1

insomnia1

stimulation1

emotional blunting1

addiction1

nausea1

vomiting1

In their own words

“tried Tianeptine Sulfate - my hero was born. From day one, and every day after, I've experienced massive bronchodilation for a notably extended period of time with no noticeable crash whatsoever.”

HelpedRead the discussion ↗

“Tianeptine sulfate 25 mg only did negative things to me...Made my head foggy, increased anxiety, decreased motivation, didn't lift mood.”

Didn't helpRead the discussion ↗

“I've tried doses of sulfate up to 150mg... I felt 'good' as in a good sense of well being, but nothing bordering euphoric... nausea and vomiting at the 150mg dose.”

MixedRead the discussion ↗

“I've had little to no effect from tianeptine. I dosed daily for two weeks at the start of my day and only noticed a slight deadening of emotions”

Didn't helpRead the discussion ↗

“today for the first time I took 40mg tianeptine sulfate with my zoloft. It's been about 6 hours since and I feel great, finally normal, happy”

HelpedRead the discussion ↗

“I was pretty depressed and negative on the tianeptine alone...so its quite the turn around.”

MixedRead the discussion ↗

Is Tianeptine Sulfate safe? What the research covers

AResearch: Strong18 meta-analyses · 42 randomized trials on PubMed

Mol Psychiatry · 2023

Antidepressants for the treatment of adults with major depressive disorder in the maintenance phase: a systematic review and network meta-analysis

Conclusion: Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting. In conclusion, desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.

J Child Psychol Psychiatry · 2021

Practitioner Review: Pharmacological treatment of attention-deficit/hyperactivity disorder symptoms in children and youth with autism spectrum disorder: a systematic review and meta-analysis

Conclusion: Direct pooled evidence supports the efficacy and tolerability of methylphenidate or atomoxetine for treatment of ADHD symptoms in children and youth with ASD. The current review highlights the efficacy of standard ADHD pharmacotherapy for treatment of ADHD symptoms in children and youth with ASD. Consideration of the benefits weighed against the limitations of safety/efficacy data and lack of data evaluating long-term continuation is undertaken to help guide clinical decision-making regarding treatment of co-occurring ADHD symptoms in children and youth with ASD.

Front Psychiatry · 2020

Antidepressants in Children and Adolescents: Meta-Review of Efficacy, Tolerability and Suicidality in Acute Treatment

Conclusion: There is a paucity of data on suicidal ideation/behavior, but paroxetine may increase the risk of suicidality in the treatment of AD and venlafaxine for MDD. Findings from this review must be considered in light of potential limitations, such as the lack of comparative information about many antidepressants, the short-term outcomes and the quality of the available evidence.