PlainPill

Selegiline Hcl

The short answer. There isn't much data on Selegiline Hcl yet — 2 mentions, 2 with a clear outcome — so treat these numbers as anecdotal. It is well studied (as Selegiline) — 64 meta-analyses on PubMed.

What users report
50%helped2 reports · few reports
1 helped0 mixed1 didn't help

From 2 mentions in total — the rest didn't say how it went and aren't counted.

Clinical research
AStrong research basefor Selegiline in general
64
meta-analyses
153
RCTs
1,670
papers

What Selegiline Hcl does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research basefor Selegiline in general

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found. Studies usually look at Selegiline in general rather than this specific form, so the research shown is for Selegiline.

BMJ Ment Health · 2025 · Meta-analysis / systematic review
Effectiveness of pharmacological and non-pharmacological interventions for treatment-resistant depression in older patients: a systematic review and meta-analysis

Conclusion: We identified weak evidence that ketamine therapy and aripiprazole augmentation, and very weak evidence that TMS, PGP and cognitive remediation increased remission. Lack of evidence regarding routinely prescribed antidepressants and psychosocial treatments is problematic, requiring clinicians to extend evidence from younger populations.

PubMed 40032553 ↗
Cochrane Database Syst Rev · 2018 · Meta-analysis / systematic review
Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders

Conclusion: Following an updated search of potentially relevant studies, we found no new studies that matched our inclusion criteria and thus our conclusions have not changed.Methylphenidate, clonidine, guanfacine, desipramine, and atomoxetine appear to reduce ADHD symptoms in children with tics though the quality of the available evidence was low to very low. Although stimulants have not been shown to worsen tics in most people with tic disorders, they may, nonetheless, exacerbate tics in individual cases. In these instances, treatment with alpha agonists or atomoxetine may be an alternative. Although th

PubMed 29944175 ↗
Curr Neuropharmacol · 2022 · Meta-analysis / systematic review
How to Optimize the Effectiveness and Safety of Parkinson's Disease Therapy? - A Systematic Review of Drugs Interactions with Food and Dietary Supplements

Conclusion: We found evidence for levodopa positive interaction with coffee, fiber and vitamin C, as well as for the potential beneficial impact of low-fat and protein redistribution diet. Contrastingly, high-protein diet and ferrous sulfate supplements can negatively affect levodopa pharmacokinetics and effectiveness. For other drugs, the data of food impact are scarce. Based on the available limited evidence, all dopamine agonists (bromocriptine, cabergoline, ropinirole), tolcapone, rasagiline, selegiline in tablets, safinamide, amantadine and pimavanserin can be taken with or without a meal. Opicapone

PubMed 34784871 ↗

Dosage people report

We don't list doses for prescription medications. Dosing should only come from a doctor or pharmacist.

Reported side effects

How often each side effect came up across all reports.

No side effects reported so far.

What users say

First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.

“one of the most effective combinations I have had for ADD is Selegiline HCL + DLPA(low dose).”
HelpedRead the discussion ↗
Top discussions (2)

Other options for focus

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate