PlainPill

R-Lipoic Acid

People mainly take R-Lipoic Acid for focus. Based on 5 first-hand reports and 0 meta-analyses & systematic reviews in the medical literature. Ranked #1307 of 1,974 overall.

14
User score
Mostly positive
20% positive0% mixed0% negative80% unclear

Of reports that state an outcome, 100% are positive.

Clinical research
CLimited research
0
meta-analyses
2
RCTs
53
papers

What R-Lipoic Acid does, according to users

Of the people who reported each effect, the share who said it got better.

betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

CLimited research

1–4 randomized controlled trials, no meta-analysis yet. The grade measures how much human research exists — read the conclusions below for what it found.

No meta-analyses or systematic reviews published yet — 2 randomized trials found.

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

200 mgtwice daily
500 mg3x daily
200 mg2x daily

Reported side effects

How often each side effect came up across all reports.

No side effects reported so far.

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“For me, choline or R-lipoic acid are much more effective”
Source discussion ↗
“Try 200 mg R-Lipoic Acid, 20 mg PQQ, and 500 mg Acetyl L-Carnitine (ALCAR) twice per day.”
Source discussion ↗
“500mg ALCAR + R-lipoic acid”
Source discussion ↗
“500mg R-lipoic acid.”
Source discussion ↗
“R-Lipoic Acid has helped my brain fog. I take 200mg 2x daily”
Source discussion ↗
Top discussions (5)

Other options for focus

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate