Across 319 first-hand reports, people mentioned a side effect 12 times (about 4 per 100 reports). The most common: mania, hppd, psychosis risk. User reports show what people notice — they can't tell you whether Psilocybin is safe for you.
“doing shrooms helped a lot. I felt really peaceful...This slowly went away, and was gone the next day.”
Conclusion: A review of open-label trials showed robust decreases in depressive symptoms following psilocybin administration. These findings provide preliminary evidence for antidepressant efficacy with psilocybin-assisted psychotherapy, however, further studies are needed to evaluate safety and efficacy and to optimize treatment protocols.
Conclusion: Nearly a third of the articles reported that no participants reported lasting adverse effects. Our analyses suggest that psychedelics reduce negative mood, and have potential efficacy in other mental disorders, such as substance-use disorders and PTSD.
Conclusion: In conclusion, we discovered specific ED95 values for different populations, indicating higher ED95 values for treatment-resistant depression, primary depression, and secondary depression groups. Further RCTs are necessary for each population to determine the optimal dosage, allowing for maximum efficacy while minimizing side effects.