JAMA Netw Open · 2026
Psychological Therapy Quantity and Depressive Symptom Reduction in Psychedelic-Assisted Therapy: A Systematic Review and Meta-AnalysisDoes Psilocybin Microdose help with mood?
Possibly — but there are few reports. 100% of 11 people who reported on Psilocybin Microdose for mood say it improved. 0% noticed no change and 0% say it got worse.
Mood: what users report
100%better11 reports · few reports
11 better0 no change0 worse
What people say about Psilocybin Microdose and mood
“First time was great, but I got nausea every other time.”
“I found it has made me a lot more creative and better at thinking outside the box.”
“I went down the adderall and vyvanse rabbit hole... Still had some profoundly negative impacts on my life... micro dosing psilocybin helps alot ...like it helped me ALOT!”
“microdosing mushrooms have been life changing for my anhedonia”
What the research says
BResearch: Moderate13 meta-analyses · 0 trials on PubMed
Side effects people mention
nausea 1drowsiness 1
Based on few reports — treat as anecdotal. Information only — not medical advice. How we count