PlainPill
SubstanceLibidoMoodPain & inflammation

Progesterone Cream

People mainly take Progesterone Cream for libido, mood, pain & inflammation. Based on 8 first-hand reports and 0 meta-analyses & systematic reviews in the medical literature. Ranked #709 of 3,539 overall.

Compare with…Alternatives for libido
28
User score
Mostly positive
50% positive0% mixed0% negative50% unclear

Of reports that state an outcome, 100% are positive.

Clinical research
BModerate research base
0
meta-analyses
13
RCTs
30
papers

What Progesterone Cream does, according to users

Of the people who reported each effect, the share who said it got better.

Libido100% of 2Mood100% of 1Pain & inflammation100% of 1
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

BModerate research base

At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.

No meta-analyses or systematic reviews published yet — 13 randomized trials found.

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

before bedas reported
ovulation to first day of periodas reported
dailyas reported
10 mgevening, from day 3 after ovulation until period

Reported side effects

How often each side effect came up across all reports.

No side effects reported so far.

What users say

First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.

“At about 35 I started using progesterone cream. It helps balance hormones...It really helped with my sex drive”
HelpedRead the discussion ↗
“Progesterone cream, ovulation to first day of period. I had brain surgery that left me with cognitive problems that I thought I wouldn't recover from. I did.”
HelpedRead the discussion ↗
“Progesterone cream shortened my period by half. I was up to 12 days at the time. I used 10mg bioidentical cream in the evening, from day 3 after ovulation until period.”
HelpedRead the discussion ↗
Top discussions (5)

Other options for libido

Maca
Supplement · 299 reports
51
88% report better libido
MixedAResearch: Strong
Tongkat Ali
Supplement · 704 reports
40
77% report better libido
MixedBResearch: Moderate
Tadalafil
Medication · 214 reports
65
91% report better libido
Mostly positiveAResearch: Strong
Zinc
Supplement · 1,264 reports
42
88% report better libido
Mostly positiveAResearch: Strong
Testosterone
Medication · 822 reports
54
93% report better libido
Mostly positiveAResearch: Strong
PT-141
Peptide · 103 reports
56
94% report better libido
MixedCResearch: Limited

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate