What are the side effects of Prednisone?

Users most often report mania, side effects, agitation, insomnia, weight gain. Side effects came up 9 times across 15 reports.

User reports can't establish safety. PubMed lists 608 meta-analyses and 3,012 randomized trials. Talk to a doctor or pharmacist, especially if you take other medication.

Prednisone side effects

Across 15 first-hand reports, people mentioned a side effect 9 times (about 60 per 100 reports). The most common: mania, side effects, agitation. User reports show what people notice — they can't tell you whether Prednisone is safe for you.

Reported side effects

mania2

side effects1

agitation1

insomnia1

weight gain1

muscle wasting1

muscle weakness1

suppression1

In their own words

“It was probably the best I have ever felt because I actually had energy for once.”

HelpedRead the discussion ↗

“When I was really sick I was on prednisone and opioids and my T levels got to 190ng/dL.”

Didn't helpRead the discussion ↗

“I have a prescription for prednisone, so I took 40 mg. I was beaming with energy all day”

HelpedRead the discussion ↗

Is Prednisone safe? What the research covers

AResearch: Strong608 meta-analyses · 3,012 randomized trials on PubMed

J Clin Endocrinol Metab · 2024

Neuropsychiatric Adverse Effects of Synthetic Glucocorticoids: A Systematic Review and Meta-Analysis

Conclusion: The heterogeneity of glucocorticoid use is reflected in the available studies. Despite this heterogeneity, the proportion of neuropsychiatric adverse effects in glucocorticoid users is high. The most substantial associations with glucocorticoid use were found for depression and mania. Upon starting glucocorticoid treatment, awareness of possible psychiatric side effects is essential. More structured studies on incidence and potential pathways of neuropsychiatric side effects of prescribed glucocorticoids are clearly needed.

J Allergy Clin Immunol Pract · 2024

Efficacy and Safety of Systemic Corticosteroids for Urticaria: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Conclusion: Systemic corticosteroids for acute urticaria or chronic urticaria exacerbations likely improve urticaria, depending on antihistamine responsiveness, but also likely increase adverse effects in approximately 15% more.