Lancet · 2025
The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysisConclusion: We found strong evidence that antidepressants differ markedly in their physiological effects, particularly for cardiometabolic parameters. Treatment guidelines should be updated to reflect differences in physiological risk, but choice of antidepressant should be made on an individual basis, considering clinical presentation and preferences of patients, carers, and clinicians.