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Pentosan Polysulfate side effects

Across 16 first-hand reports, people mentioned a side effect 6 times (about 38 per 100 reports). The most common: eye issues, dry skin, gallbladder discomfort. User reports show what people notice — they can't tell you whether Pentosan Polysulfate is safe for you.

Reported side effects

eye issues1
dry skin1
gallbladder discomfort1
liver discomfort1
diarrhea1
headache1

In their own words

“I must say that Pentosan has been incredibly effective in improving my quality of life and allowing me to return to my breakdancing practice.”
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Is Pentosan Polysulfate safe? What the research covers

AResearch: Strong20 meta-analyses · 27 randomized trials on PubMed
BMJ Clin Evid · 2011
Chronic prostatitis

Conclusion: In this systematic review, we present information relating to the effectiveness and safety of the following interventions: 5 alpha-reductase inhibitors, allopurinol, alpha-blockers, biofeedback, local injections of antimicrobial drugs, mepartricin, non-steroidal anti-inflammatory drugs (NSAIDs), oral antimicrobial drugs, pentosan polysulfate, prostatic massage, quercetin, radical prostatectomy, sitz baths, transurethral microwave thermotherapy, and transurethral resection.

BMJ Clin Evid · 2008
Chronic prostatitis

Conclusion: In this systematic review we present information relating to the effectiveness and safety of the following interventions: 5 alpha-reductase inhibitors, allopurinol, alpha-blockers, biofeedback, local injections of antimicrobial drugs, mepartricin, non-steroidal anti-inflammatory drugs, oral antimicrobial drugs, pentosan polysulfate, prostatic massage, quercetin, radical prostatectomy, sitz baths, transurethral microwave thermotherapy, and transurethral resection.

Urology · 2021
Pentosan Polysulfate Maculopathy: What Urologists Should Know in 2020

Conclusion: Although the nature of the published studies renders them prone to confounders, currently available data suggest an increased risk for developing maculopathy after years of pentosan polysulfate sodium use. In light of this, and the marginal effectiveness of the medication for the average individual, we suggest that education be provided as to the possible association and that regular ophthalmic evaluation be recommended for patients who are continued on chronic Pentosan Polysulfate Sodium.

Pentosan Polysulfate side effects: what 16 users report — PlainPill