Across 75 first-hand reports, people mentioned a side effect 6 times (about 8 per 100 reports). The most common: fatigue, insomnia, wired but. User reports show what people notice — they can't tell you whether P21 is safe for you.
High-risk compound. Not an approved supplement; serious and sometimes irreversible risks, banned in sport, may be restricted where you live.
“P21 was a strange combination of unpleasant stimulation and lethargy, which had a pretty negative impact on my sleep.”
“I had high hopes for all of these, and all were helpful in their own way, but I can't say I've noticed any long-term benefits from any of them.”
“It doesn’t exactly feel like flipping on a switch to consciousness, and it can make me a bit drowsy.”
“It made me very talkative and focused. It also made me a little tired after a while.”
“I have insulfated what appeared to be in th 2mg-7mg range. ... I did notice an almost instantaneous brightening of sensory awareness”
Conclusion: Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies.
Conclusion: This is the first investigation of cancer risk in KRAS or HRAS PV-positive mosaic RASopathies to date. The high incidence and SIR values found highlight the need for rigorous RMS surveillance in young children and skin cancer surveillance in adults with this high-risk condition.