Conclusion: Nearly a third of the articles reported that no participants reported lasting adverse effects. Our analyses suggest that psychedelics reduce negative mood, and have potential efficacy in other mental disorders, such as substance-use disorders and PTSD.
Does MDMA help with mood?
For some people. 59% of 29 people who reported on MDMA for mood say it improved. 7% noticed no change and 34% say it got worse. That is below the typical result for mood (84% across 108 options).
Mood: what users report
59%better29 reports · medium confidence
17 better2 no change10 worse
Ranked #94 of 108 for mood.
What people say about MDMA and mood
“I feel that MDMA changed my personality forever, in a good way.”
“Probably great for PTSD but it did nothing really for me. I mean great experience but against depressive or anxiety symptoms it doesn't do shit long-term.”
“I don't feel I ever fully recovered and that's been over 20 years now. I can still remember the lows afterwards like yesterday.”
“I took my 200mg dose and felt absolutely nothing. The only thing I got out of it was the inability to sleep, and urinate.”
What the research says
AResearch: Strong99 meta-analyses · 165 trials on PubMed
Psychiatry Res · 2024
Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysisBMJ · 2024
Comparative oral monotherapy of psilocybin, lysergic acid diethylamide, 3,4-methylenedioxymethamphetamine, ayahuasca, and escitalopram for depressive symptoms: systematic review and Bayesian network meta-analysisConclusion: Of the available psychedelic treatments for depressive symptoms, patients treated with high dose psilocybin showed better responses than those treated with placebo in the antidepressant trials, but the effect size was small.
Expert Opin Pharmacother · 2023
Psychedelics for treatment resistant depression: are they game changers?Side effects people mention
neurotoxicity 6anxiety 4fatigue 3anhedonia 2overheating 1
What else is MDMA used for?
Information only — not medical advice. How we count