People mainly take Matrine for pain & inflammation, anxiety, mood. Based on 13 first-hand reports and 15 meta-analyses & systematic reviews in the medical literature. Ranked #1227 of 3,539 overall.
Of reports that state an outcome, 74% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Given the poor methodological quality of the evidence currently available, future high-quality, three-blinded randomized control trials are necessary to confirm these results. Copyright © 2017 John Wiley & Sons, Ltd.
PubMed 28382770 ↗Conclusion: As an important traditional Chinese medicine, modern pharmacological studies have demonstrated that S. alopecuroides has prominent bioactivities, especially on gynecological inflammation and hepatitis B, and anticancer activities. These activities provide prospects for novel drug development for cancer and some chronic diseases. Nevertheless, the comprehensive evaluation, quality control, understanding of the multitarget network pharmacology, long-term in vivo toxicity, and clinical efficacy of S. alopecuroides require further detailed research.
PubMed 31442619 ↗Conclusion: Kushen gel significantly enhances HPV clearance and reduces recurrence with a favorable safety profile, supporting its potential as a non-invasive therapeutic option for women with HR-HPV infection.
PubMed 41281996 ↗Conclusion: Conclusion: Matrine has bidirectional effects on the liver at doses ranging from 10 to 69.1 mg/kg by influencing Ca2+ homeostasis in the cytoplasm, endoplasmic reticulum, Golgi apparatus, and mitochondria. Systematic review registration: https://inplasy.com/, identifier INPLASY202340114.
PubMed 38348397 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.
“Matrine for the pain. NSAIDs can also help. Yes, I mean for mental and emotional pain.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate