Int J Mol Sci · 2025
Natural Products in Alzheimer's Disease: A Systematic Review of Clinical Trials and Underlying Molecular MechanismsConclusion: Curcumin and Melissa officinalis had limited effects, resveratrol showed mixed outcomes with some side effects, and matcha green tea may improve cognition and sleep quality. Despite generally favorable results, the studies varied considerably in design and quality; nonetheless, herbal extracts represent a prominent category of natural interventions in AD and MCI, underscoring the need for further large-scale, high-quality clinical trials to confirm their therapeutic potential.