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L-Arginine side effects

Across 211 first-hand reports, people mentioned a side effect 16 times (about 8 per 100 reports). The most common: diarrhea, stomach issues, chest pain. User reports show what people notice — they can't tell you whether L-Arginine is safe for you.

Reported side effects

diarrhea5
stomach issues5
chest pain1
tongue biting1
viral infection1
indigestion1
cold sores1
headache1

In their own words

“I tried so many things – L-Arginine, Citrulline, Zinc, Omega-3s, training, clean diet. Some things helped a bit, but nothing really fixed it.”
Didn't helpRead the discussion ↗
“I also started taking L-Arginine with it as I had a bunch of pills but to be honest I didn't notice any added pump at all.”
Didn't helpRead the discussion ↗
“I tried different forms and dosages of Magnesium, Zinc, L-Tyrosine, melatonin, L-Arginine, ALPHA-GPC... most of them didn't provide any meaningful and noticeable benefits”
Didn't helpRead the discussion ↗
“two weeks of arginine supplementation seemed like it rolled back easily a year or two of old injuries... best sleep of my life... bite my tongue more often”
MixedRead the discussion ↗

Is L-Arginine safe? What the research covers

AResearch: Strong106 meta-analyses · 765 randomized trials on PubMed
J Am Coll Cardiol · 2022
Micronutrient Supplementation to Reduce Cardiovascular Risk

Conclusion: Supplementation of some but not all micronutrients may benefit cardiometabolic health. This study highlights the importance of micronutrient diversity and the balance of benefits and risks to promote and maintain cardiovascular health in diverse populations. (Antioxidant Supplementation in the Prevention and Treatment of Cardiovascular Diseases; CRD42022315165).

Curr Cardiol Rev · 2021
Cardiovascular Changes in Menopause

Conclusion: The increased cardiovascular risk in menopause stems from the exaggerated effects of changing physiology on the cardiovascular system affecting peripheral, cardiac and cerebrovascular beds. The differential effects of menopause on cardiovascular disease at the subclinical, biochemical and molecular levels form the highlights of this review.

L-Arginine side effects: what 211 users report — PlainPill