What are the side effects of L-Citrulline?

Users most often report cold sore, dizziness, headache, increased urination, eye bags. Side effects came up 8 times across 231 reports.

L-Citrulline side effects

Q: Is L-Citrulline safe?

User reports can't establish safety. PubMed lists 14 meta-analyses and 101 randomized trials. Talk to a doctor or pharmacist, especially if you take other medication.

Across 231 first-hand reports, people mentioned a side effect 8 times (about 3 per 100 reports). The most common: cold sore, dizziness, headache. User reports show what people notice — they can't tell you whether L-Citrulline is safe for you.

Reported side effects

cold sore1

dizziness1

headache1

increased urination1

eye bags1

tooth damage1

herpes outbreak1

blood pressure1

In their own words

“I'd say 95% of them are gone the few that remain I notice every few days if I try to focus on them they are fainter and fainter.”

HelpedRead the discussion ↗

“I have already used citrulline as one of the forms described in the post. Citrulline didn't seem to do anything either”

Didn't helpRead the discussion ↗

Is L-Citrulline safe? What the research covers

AResearch: Strong14 meta-analyses · 101 randomized trials on PubMed

J Am Coll Cardiol · 2022

Micronutrient Supplementation to Reduce Cardiovascular Risk

Conclusion: Supplementation of some but not all micronutrients may benefit cardiometabolic health. This study highlights the importance of micronutrient diversity and the balance of benefits and risks to promote and maintain cardiovascular health in diverse populations. (Antioxidant Supplementation in the Prevention and Treatment of Cardiovascular Diseases; CRD42022315165).