Hrt/TRT
The short answer. There isn't much data on Hrt/TRT yet — 2 mentions, 1 with a clear outcome — so treat these numbers as anecdotal.
What users report
100%helped1 reports · few reports
1 helped0 mixed0 didn't help
From 2 mentions in total — the rest didn't say how it went and aren't counted.
Clinical research
Not graded
What Hrt/TRT does, according to users
Of the people who reported each effect, the share who said it got better.
betterno changeworse
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
Research data for Hrt/TRT is being compiled.
Dosage people report
We don't list doses for prescription medications. Dosing should only come from a doctor or pharmacist.
Reported side effects
How often each side effect came up across all reports.
No side effects reported so far.
What users say
First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.
No first-hand experiences with a clear outcome yet.
Other options for mood
Probiotics
Supplement
AResearch: Strong
Tianeptine
Medication
AResearch: Strong
Ketamine
Medication
AResearch: Strong
Bromantane
Supplement
BResearch: Moderate
Saffron
Supplement
AResearch: Strong
Kanna
Supplement
BResearch: Moderate
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate