Conclusion: Conclusions: Though some DSs showed potential in reducing fatigue in ME/CFS, methodological limitations and inconsistent results hinder definitive conclusions. Future research should improve diagnostic criteria and include more diverse populations.
PubMed 39940333 ↗Guanidinoacetic Acid
Based on 4 first-hand reports and 2 meta-analyses & systematic reviews in the medical literature. Ranked #3101 of 4,149 overall.
Of reports that state an outcome, 0% are positive.
What Guanidinoacetic Acid does, according to users
Of the people who reported each effect, the share who said it got better.
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: The meta-refgression suggested that 0.06% GAA supplementation increased final body weight by approximately 2.11% (60 g) in Ross 308 broilers. Collectively, the results confirm that GAA exerts a robust, dose-limited benefit of growth efficiency in broiler chickens, thereby supporting its incorporation into Arg or energy deficient diets that would have potential economic benefit.
PubMed 41759464 ↗Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.
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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate