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Fluoxetine side effects

Across 119 first-hand reports, people mentioned a side effect 15 times (about 13 per 100 reports). The most common: sexual dysfunction, fatigue, headache. User reports show what people notice — they can't tell you whether Fluoxetine is safe for you.

Reported side effects

sexual dysfunction6
fatigue2
headache2
anorgasmia1
pssd1
ed1
libido loss1
zombification1

What got worse for some people

In their own words

“Prozac at 21 stole most of my libido. Found myself getting into riskier situations to feel the rush of desire I used to have much more organically.”
Didn't helpRead the discussion ↗
“Prozac made me teen times worse. I was so much better off taking Wellbutrin all alone.”
Didn't helpRead the discussion ↗
“I'm on the third day and it's been very effective. positive for those who have a slight depression or anxiety, want a slight boost, it's great.”
MixedRead the discussion ↗
“Fluoxetine helped tremendously for acute symptoms, but left me a bit apathic afterwards.”
MixedRead the discussion ↗
“After I was diagnosed with ocd I was put on Prozac for years but the side effects are numerous and I got to the point where I preferred just dealing with the ocd than feeling like a zombie.”
MixedRead the discussion ↗
“I have tried Prozac in the past (not together with Noopept though) and did not help much, even at a very high dose.”
Didn't helpRead the discussion ↗

Is Fluoxetine safe? What the research covers

AResearch: Strong534 meta-analyses · 1,257 randomized trials on PubMed
Mol Psychiatry · 2023
Antidepressants for the treatment of adults with major depressive disorder in the maintenance phase: a systematic review and network meta-analysis

Conclusion: Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting. In conclusion, desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.

Fluoxetine side effects: what 119 users report — PlainPill