What are the side effects of Dxm?

Users most often report brain fog, serotonin syndrome, blackouts, respiratory depression, nausea. Side effects came up 9 times across 52 reports.

User reports can't establish safety. PubMed lists 11 meta-analyses and 66 randomized trials. Talk to a doctor or pharmacist, especially if you take other medication.

Dxm side effects

Across 52 first-hand reports, people mentioned a side effect 9 times (about 17 per 100 reports). The most common: brain fog, serotonin syndrome, blackouts. User reports show what people notice — they can't tell you whether Dxm is safe for you.

Reported side effects

brain fog2

serotonin syndrome1

blackouts1

respiratory depression1

nausea1

impaired balance1

depression1

social phobia1

In their own words

“DXM did nothing to me except for nausea and ugly feeling to be honest.”

Didn't helpRead the discussion ↗

“It [DXM] works great for me at low levels. I usually take 60-120mg a few days a week and it yas been incredibly helpful for my depression and anxiety.”

MixedRead the discussion ↗

“I had chronic mild serotonin syndrome from dxm... It’s been 4 years sober, it’s taken years to feel somewhat normal.”

Didn't helpRead the discussion ↗

“I tried DXM but only got trivial results (could be because today is my first trying it in the form of delsym, which is time released).”

Didn't helpRead the discussion ↗

“I've used DXM in the past for its antidepressant effects - It ruins my cognition for the next day though.”

MixedRead the discussion ↗

“I did some DXM even a week after my last curcumin dose and when I peaked I got brain zaps and OEVs just from a normal 10ml cough dose along with borderline panic attacks.”

Didn't helpRead the discussion ↗

Is Dxm safe? What the research covers

AResearch: Strong11 meta-analyses · 66 randomized trials on PubMed

Front Psychiatry · 2021

Focus on Over-the-Counter Drugs' Misuse: A Systematic Review on Antihistamines, Cough Medicines, and Decongestants

Conclusion: Conclusion: Results from the systematic review showed that the OTC misusing issues are both widespread worldwide and popular; vulnerable categories include adolescents and young adults, although real prevalence figures remain unknown, due to a lack of appropriate monitoring systems. Considering the potential, and at times serious, adverse effects associated with OTC misusing issues, healthcare professionals should be vigilant, and ad hoc preventative actions should be designed and implemented.

Clin Neurol Neurosurg · 2024

Comparative efficacy of dexamethasone versus surgery for chronic subdural hematoma: A systematic review and meta-analysis

Conclusion: DXM had a significantly higher incidence of secondary surgical intervention. However, there was no difference regarding mortality and other safety outcomes between surgery and DXM for the patients with CSDH. Observational studies showed that DXM was associated with a lower risk of poor postoperative outcomes within hospital stay and had shorter duration of hospital stay, but the recurrence rate was lower in the surgery group.

Medicine (Baltimore) · 2023

Methylprednisolone or dexamethasone? How should we choose to respond to COVID-19?: A systematic review and meta-analysis of randomized controlled trials

Conclusion: The results of this meta-analysis showed that there was no difference in mortality, ICU admission rate, hospital stay, mechanical ventilation, or adverse events between MP and DXM in the treatment of COVID-19. The incidence of hyperglycemia with methylprednisolone was higher than that with dexamethasone.