PlainPill
SupplementMoodAnxietyHormones

Dioscorea Nipponica

The short answer. There isn't much data on Dioscorea Nipponica yet — 19 mentions, 9 with a clear outcome — so treat these numbers as anecdotal. It is most often used for mood: 80% of 5 reports say that improved. There is a moderate body of research — 1 meta-analyses and 1 trials.

Compare with…Alternatives for mood
What users report
67%helped9 reports · few reports
6 helped3 mixed0 didn't help

From 19 mentions in total — the rest didn't say how it went and aren't counted.

Clinical research
BModerate research base
1
meta-analyses
1
RCTs
131
papers

What Dioscorea Nipponica does, according to users

Of the people who reported each effect, the share who said it got better.

Mood80% of 5Anxiety100% of 4Hormones100% of 4
4 more with fewer than 3 reports
Focus100% of 2Performance100% of 2Libido100% of 2Energy100% of 1
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

BModerate research base

At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.

J Ethnopharmacol · 2025 · Meta-analysis / systematic review
Dioscorea nipponica Makino: Unraveling multi-target mechanisms and clinical potential in autoimmune disease therapy

Conclusion: DnM exerts multi-target effects by modulating key inflammatory and apoptotic pathways in ADs. The NF-κB, STAT3, and TGF-β/Smad signaling pathways may serve as key targets for DnM in modulating inflammatory states in ADs, while Fas/FasL and Bax/Bcl-2 are potential mediators of its apoptosis-regulating effects. Clinical evidence supports its efficacy in rheumatoid arthritis (RA) and Hashimoto's thyroiditis (HT), highlighting its multi-faceted therapeutic potential. This review systematically summarizes DnM's clinical outcomes, mechanisms, and toxicological profile, however, large-scale randomize

PubMed 40633860 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

400 mgas reported
1 capmorning

Reported side effects

How often each side effect came up across all reports.

hair loss ×1aggression ×1emotional instability ×1

What users say

First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.

“It's hard to put a finger on its effects, but it's calming to me in a very unique way”
HelpedRead the discussion ↗
“Dioscorea nipponica hands down. But it made me lose my hair so I had to stop.”
MixedRead the discussion ↗
“gave me a calmer masculinity that wasn't stimulating...it gave me way too aggressive in uncomfortable situations...tribulus aggression”
MixedRead the discussion ↗
Top discussions (3)

Dioscorea Nipponica compared

vs Dioscorea

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate