PlainPill

Devil's Claw

People mainly take Devil's Claw for pain & inflammation. Based on 8 first-hand reports and 7 meta-analyses & systematic reviews in the medical literature. Ranked #1668 of 4,149 overall.

19
User score
Mostly positive
25% positive0% mixed12% negative62% unclear

Of reports that state an outcome, 68% are positive.

Clinical research
BModerate research base
7
meta-analyses
3
RCTs
131
papers

What Devil's Claw does, according to users

Of the people who reported each effect, the share who said it got better.

betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

BModerate research base

At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.

Cochrane Database Syst Rev · 2014 · Meta-analysis / systematic review
Herbal medicine for low-back pain

Conclusion: C. frutescens (Cayenne) reduces pain more than placebo. Although H. procumbens, S. alba, S. officinale L., S. chilensis, and lavender essential oil also seem to reduce pain more than placebo, evidence for these substances was of moderate quality at best. Additional well-designed large trials are needed to test these herbal medicines against standard treatments. In general, the completeness of reporting in these trials was poor. Trialists should refer to the CONSORT statement extension for reporting trials of herbal medicine interventions.

PubMed 25536022 ↗
Spine (Phila Pa 1976) · 2016 · Meta-analysis / systematic review
Herbal Medicine for Low Back Pain: A Cochrane Review

Conclusion: Additional well-designed large trials are needed to test these herbal medicines against standard treatments. In general, the completeness of reporting in these trials was poor. Trialists should refer to the CONSORT statement extension for reporting trials of herbal medicine interventions.

PubMed 26630428 ↗
Recent Adv Food Nutr Agric · 2024 · Meta-analysis / systematic review
A Systemic Review on Nutraceutical Supplements used in the Management of Osteoarthritis

Conclusion: The evaluation covers every potential nutraceutical utilized in osteoarthritis, together with its supporting data and mode of action. The present review discusses nutraceuticals, including devil's claw, vitamin D, boswellic acid, capsaicin, ginger, curcumin, krill oil, ginger, and avocado/soybean unsaponifiable.

PubMed 38258782 ↗
Cochrane Database Syst Rev · 2006 · Meta-analysis / systematic review
Herbal medicine for low back pain

Conclusion: Harpagophytum Procumbens, Salix Alba and Capsicum Frutescens seem to reduce pain more than placebo. Additional trials testing these herbal medicines against standard treatments are needed. The quality of reporting in these trials was generally poor. Trialists should refer to the CONSORT statement extension for reporting trials of herbal medicine interventions.

PubMed 16625605 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

300 mgdaily
600 mgas reported

Reported side effects

How often each side effect came up across all reports.

No side effects reported so far.

What users say

First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.

“I tried every supplement and combination. These worked best for me.”
HelpedRead the discussion ↗
“Nothing helps. My pain is getting worse, im crashing constantly.”
Didn't helpRead the discussion ↗
“I'm started getting Rheumatism and have been taking an alcohol tincture of Devil's Claw.”
Read the discussion ↗
Top discussions (5)

Other options for pain & inflammation

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate