Conclusion: K-Ras and p53 mutation both contribute to biliary tract carcinoma. K-Ras mutation, however, has a much higher frequency compared to p53 inactivation in such cancers.
PubMed 34974575 ↗Animal Pak
The short answer. There isn't much data on Animal Pak yet — 8 mentions, 2 with a clear outcome — so treat these numbers as anecdotal. There is a moderate body of research — 21 meta-analyses and 0 trials.
From 8 mentions in total — the rest didn't say how it went and aren't counted.
What Animal Pak does, according to users
Of the people who reported each effect, the share who said it got better.
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Calcium uptake by TRPV5 was directly inhibited by magnesium and low pH. In summary, these data are compatible with the hypothesis that urinary magnesium directly inhibits renal calcium absorption, which can be negated by high luminal pH, and that this regulation likely takes place in the distal tubule.
PubMed 18448585 ↗Conclusion: Thus, on a restricted diet, a clear demarcation was seen between urinary calcium excretion of kidney stone formers with absorptive hypercalciuria type I and normal individuals. When dietary variables are controlled, the classic definition of hypercalciuria of nephrolithiasis appears valid.
PubMed 21775970 ↗Conclusion: In traditional medicine, this plant has been prescribed in many disorders; therefore, clinical trials on the compounds ofgundelia seem essential. This study gives an overview of traditional uses of gundelia, irrespective of pharmacological studies on its effects.
PubMed 24511731 ↗Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.
“I am really happy with taking the Universal Animal Pak every morning... I always feel much better throughout the day”
“My biggest issues with animal pak are the following: Vitamin D is obnoxiously low... The entire B-complex is dosed extremely high... 400mg of magnesium oxide taken at once is a laxative”
“Animal PAK (its supplement for bodybuilders but I highly recommend it as it has some nootropic agents which has effect on me even when taken alone”
Top discussions (5)
- Suggestions for vitamin supplements? ↗
- A Crazy thought here, but hear me out... ↗
- Help me rebuild my stack I got so much stuff here I dont want to take it all :) ↗
- (x-post) Need a little bit of advice on introducing new things into my stack ↗
- Responded to a thread about Animal Pak, decided the response is worthy of its own thread: Why I have an issue with Animal Pak and other popular daily packs. ↗
Other options for energy
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate