What are the side effects of Amphetamines?

Users most often report anxiety, addiction, skin aging, neurotoxicity, anhedonia. Side effects came up 11 times across 50 reports.

Amphetamines side effects

Q: Is Amphetamines safe?

User reports can't establish safety. PubMed lists 139 meta-analyses and 67 randomized trials. Talk to a doctor or pharmacist, especially if you take other medication.

Across 50 first-hand reports, people mentioned a side effect 11 times (about 22 per 100 reports). The most common: anxiety, addiction, skin aging. User reports show what people notice — they can't tell you whether Amphetamines is safe for you.

Reported side effects

anxiety3

addiction2

skin aging1

neurotoxicity1

anhedonia1

unclean feeling1

jitteriness1

burnout1

What got worse for some people

Anxiety60% worse · 40% better · of 5

In their own words

“Even taking pause from amphetamines for over a year or more doesn't seem to reset it for me. It works great for maybe a month or two when I'm back on them, then it's all negative side effects.”

MixedRead the discussion ↗

“I've used amphetamines too, but I don't like how unclean it makes me feel.”

Didn't helpRead the discussion ↗

“I feel good for about 40~ min and then I crash SO bad. I'm talking crippling anxiety”

Didn't helpRead the discussion ↗

“You could try to get a prescription for amphetamines but using them frequently is bad news and they (at least for me) destroy the quality of my sleep”

MixedRead the discussion ↗

“I have found marionette lines beginning to form. Started dexA almost 6 months ago.”

MixedRead the discussion ↗

“I used to be addicted to amphetamines until about one year ago. I couldn’t work properly without them.”

MixedRead the discussion ↗

Is Amphetamines safe? What the research covers

AResearch: Strong139 meta-analyses · 67 randomized trials on PubMed

Lancet Psychiatry · 2018

Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis

Conclusion: Our findings represent the most comprehensive available evidence base to inform patients, families, clinicians, guideline developers, and policymakers on the choice of ADHD medications across age groups. Taking into account both efficacy and safety, evidence from this meta-analysis supports methylphenidate in children and adolescents, and amphetamines in adults, as preferred first-choice medications for the short-term treatment of ADHD. New research should be funded urgently to assess long-term effects of these drugs.

Schizophr Bull · 2020

Transition of Substance-Induced, Brief, and Atypical Psychoses to Schizophrenia: A Systematic Review and Meta-analysis

Conclusion: Transition rates were slightly lower in older cohorts but were not affected by sex, country of the study, hospital or community location, urban or rural setting, diagnostic methods, or duration of follow-up. Substance-induced psychoses associated with cannabis, hallucinogens, and amphetamines have a substantial risk of transition to schizophrenia and should be a focus for assertive psychiatric intervention.