Across 18 first-hand reports, people mentioned a side effect 7 times (about 39 per 100 reports). The most common: headache, liver toxicity, emotional blunting. User reports show what people notice — they can't tell you whether Acetaminophen is safe for you.
“I have tried, to no great relief: eating fuck tons of ginger, upping my carbs and protein post-workout, lots and lots of cannabis, Acetaminophen + Aspirin + Ibuprofen, Milk Thistle, and increased pre and post-workout stretching.”
“I have never had much luck with aleve or Tylenol helping.”
“I recently went through analgesic rebound headaches from years of too much acetaminophen and ibuprofen”
“I always notice a mood boost from ibuprofen and paracetamol.”
Conclusion: In this study, use of ibuprofen vs acetaminophen for the treatment of fever or pain in children younger than 2 years was associated with reduced temperature and less pain within the first 24 hours of treatment, with equivalent safety.
Conclusion: Compared with placebo, NSAIDs, ketamine, and mid- to high-potency opioids are effective in reducing acute pediatric pain. NSAIDs provide the greatest benefits and least harm, suggesting that they should be the first-line therapy for acute painful conditions in children.
Conclusion: Acetaminophen use during pregnancy is associated with an increased risk for ADHD, ASD, and hyperactivity symptoms. These findings are concerning; however, results should be interpreted with caution given that the available evidence consists of observational studies and is susceptible to several potential sources of bias.