Phenibut vs Piracetam for mood
Short answer: For mood, more users report improvement with Phenibut — 90% of 181 reports, versus 74% of 116 for Piracetam.
Phenibut has 3 meta-analyses and 1 randomized trials on PubMed; Piracetam has 119 and 117.
Based on 1,030 reports about Phenibut and 1,463 about Piracetam. Not medical advice.
| Phenibut Substance | Piracetam Supplement | |
|---|---|---|
| Users say it helped | 43%helped628 reports · high confidence | 53%helped688 reports · high confidence |
| Verdict | Mixed | Mixed |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 3 / 1 | 119 / 117 |
| Mainly used for | ||
| Focus % reporting improvement | 72% (47) | 80% (458) |
| Anxiety % reporting improvement | 89% (419) | 86% (57) |
| Mood % reporting improvement | 90% (181) | 74% (116) |
| Memory % reporting improvement | 40% (5) | 89% (241) |
| Energy % reporting improvement | 79% (38) | 78% (69) |
| Common side effects | withdrawal, tolerance, addiction, dependence | headache, drowsiness, irritability, insomnia |
| Typical dose reported | 500 mg | 250 mg / daily |
Phenibut withdrawal appears to have a range of severity. It is important to recognize that patients undergoing phenibut abstinence may have progressive symptom worsening during early withdrawal. All published cases of abrupt phenibut abstinence were admitted inpatients for symptom management. Benzodiazepines or barbiturates with adjunctive baclofen appear to be the most commonly used drugs for moderate to severe withdrawal. Outpatient management via slow phenibut tapers with or without adjunctive gamma-aminobutyric acid agonist therapy may be successful. However, there is no standard treatment
Clin Toxicol (Phila), 2023 ↗“Phenibut every 3 days. Hands down most effective I've tried. Plus you wake up feeling amazing.”
High-level evidence related to pharmacological strategies for managing Lewy body dementia is rare. Strategies for important areas of need in Lewy body dementia, such as autonomic symptoms and caregiver burden, have not been investigated, nor have the views of patients and caregivers about pharmacological strategies.
Am J Psychiatry, 2015 ↗“The effects were wonderful, they still are to me-- verbal fluidity, increased motivation, quicker thinking, better recall, pro social, wake up in the morning with ZERO grogginess.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate